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劉于鵬助理教授

Yu-Peng Liu

  • 連絡電話:07-312-1101 ext. 2759 #424
  • 電子信箱:ypliu@kmu.edu.tw
  • 辦公位置:國際學術研究大樓707222研究室

專長

  • 癌症轉譯醫學
  • 幹細胞生物學
  • 神經科學

研究方向

腫瘤的發生與制癌物質誘發、基因突變與基因體多型性具有高度的相關性。近年的研究發現腫瘤起始於一群特定的細胞稱為癌症幹細胞。癌症幹細胞表現出與幹細胞相關的基因並且具有自我更新以及對於化學治療及放射線治療的抗性。在免疫缺陷的老鼠模式中,少量的癌症幹細胞便能夠產生腫瘤。

我們最近的研究發現,常用於治療非小細胞肺癌病患的鉑金屬化療藥物cisplatin,在略低於致死劑量的濃度下,會透過活化Notch訊息傳遞路徑而增加腫瘤中癌症幹細胞(CD133+)的比例。我們實驗室目前利用基因體學分析技術尋找癌症幹細胞的分子標誌,並研究與癌症抗藥性相關的基因與訊息傳遞路徑。此外我們利用基因重組技術建立CD133及其他標記分子之報導基因(reporter gene)模式,應用於高通量藥物篩選,以找出針對癌症幹細胞的新穎治療藥物。

另一方面,我們也對於上皮間質轉換(epithelial-to-mesenchymal transition, EMT)如何影響癌症幹細胞的分化與抗藥性以及對於腫瘤遠端轉移功能的調控相當有興趣。本實驗室除了基礎研究外,也與臨床醫師密切合作,建立轉譯醫學的研究平台,讓實驗室研究方向能切合臨床醫學所面對的問題。

學歷

國立成功大學生命科學研究所博士

經歷

  • 高雄醫學大學醫學系基因體醫學科助理教授(現職)
  • Department of Human Genetics at Geffen School of Medicine in University of California, Los Angeles (UCLA) 訪問研究員
  • Institute of Biodiagnostics, National Research Council of Canada 訪問研究員
  • 中央研究院基因體研究中心博士後研究
  • 國立成功大學醫學院臨床醫學研究所博士後研究

代表著作

  1. Liu, Y.P., Hsu, T.I., Liao, W.C., Chen, J.C., Zeng, Y.H., Hsiao, M.*, Lu, P.J.*, 2013. Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer. Cancer Research. Published OnlineFirst August 13, 2013; doi: 10.1158/0008-5472.CAN-13-0518. (IF=8.65, Ranking 11/196, 5.6% in Oncology category) (Accepted).
  2. Lee, Y.C., Que, J, Chen, Y.C., Lin, J.T., Liou, Y.C., Liao, P.C, Liu, Y.P., Lee, K.H., Lin, L.C., Hsiao, M., Hung, L.Y., Huang, C.Y., Lu, P.J.*, 2013. Pin1 acts as a negative regulator of the G2/M transition through an interplay with the Aurora A/hBora complex. Journal of Cell Science. 2013 Aug 22. [Epub ahead of print], doi:10.1242/jcs.121368. (IF=5.88, Ranking 38/184, 20.7% in Cell Biology) (Accepted).
  3. Cheng H.C#, Liu Y.P.#, Huang C.Y., Shan Y.S., Lin F.C., Lin L.C., Lee L, Tsai C.H., Hsiao M.*, Lu P.J.*, 2013. Loss of RUNX3 Increases Osteopontin Expression and Promotes Cell Migration in Gastric Cancer. Carcinogenesis. 2013 Jul 8. [Epub ahead of print] DOI: 10.1093/carcin/bgt218. (IF=5.64, Ranking 28/196, 14.3% in Oncology category) (# Equal contribution)
  4. Liu, Y.P., Chen, H.L., Tzeng, C.C., Lu, P.J, Lee, Y.C., Tseng, C.H., Chen, Y.L, Yang, C.N*. 2013. TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation and cell death of breast cancer cells. Breast Cancer Research and Treatment. 2013. 138:383–393 (IF=4.47, Ranking 43/196, 21.9% in Oncology category)
  5. Liu, Y.P., Yang, C.J., Huang, M.S., Yeh, C.T., Wu, A T.H., Lee, Y.C., Lai, T.C., Lee, C.H., Hsiao, Y.W., Lu, J., Shen, C.N., Lu, P.J.*, Hsiao, M.*, 2013. Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Research. 2013. 73(1):406-16. (IF=8.65, Ranking 11/196, 5.6% in Oncology category)
  6. Tsai H.Y., Yang Y.F., Wu A., Yang C.J., Liu Y.P., Jan Y.H., Lee C.H., Hsiao Y.W., Yeh C.T., Shen C.N., Lu P.J., Huang M.S., Hsiao M.*, 2012. Endoplasmic reticulum ribosome binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.514. [Epub ahead of print] (IF=7.36, Ranking 19/196, 9.7% in Oncology category)
  7. Liu, Y.P. and Hsiao M.*, 2013 Exercise-induced SPARC prevents tumorigenesis of colon cancer. Gut. 2013. 62(6):810-1. Invited Commentary. (IF=10.73, Ranking 3/74, 4.1% in Gastroenterology & Hepatology category)
  8. Chang, Y.K., Liu, Y.P., Ho, J.H., Hsu, S.C., Lee, O.K.*, 2012. Amine-surface-modified superparamagnetic iron oxide nanoparticles interfere with differentiation of human mesenchymal stem cells. J Orthop Res. 2012. 30(9): 1499-506. (IF=2.88, Ranking 7/63, 11.1% in Orthopedics category)
  9. Lin, F.C.#, Liu, Y.P.#, Lai, C.H., Shan, Y.S, Cheng, H.C., Hsu, P.I., Lee, C.H., Lee, Y.C., Wanf, H.Y., Wang, C.H., Cheng, J.Q., Hsiao, M.*, Lu, P.J.* 2012. RUNX3-mediated Transcriptional Inhibition of Akt Suppresses Tumorigenesis of Human Gastric Cancer Cells. Oncogene. 2012 Sep 27;31(39):4302-16. (IF=7.36, Ranking 19/196, 9.7% in Oncology category) (# Equal contribution)
  10. Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y.P., Zhang J, Xue Z, Cheng L, Fan G*. 2012. Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. J Neurosci Res. 2012 Oct;90(10):1883-91 (IF=2.97, Ranking 118/251, 47.0% in Neuroscience category).
  11. Liu, Y.P., Yang, C.S., Chen, M.C., Sun, S.H., Tzeng, S.F.* 2010. Ca2+-dependent reduction of glutamate aspartate transporter Glast expression in astrocytes by persistent P2X7 receptor stimulation. J Neurochem. 2010. 113(1): 213-27. (IF=3.97, Ranking 59/243, 24.3% in Neuroscience category)
  12. Liu, Y.P., Yang, C.S., Tzeng, S.F.* 2008. Inhibitory regulation of glutamate aspartate transporter GLAST in astrocytes by cadmium-induced calcium influx. J Neurochem. 2008. 105(1):137-50. (IF=3.97, Ranking 59/243, 24.3% in Neuroscience category)
  13. Yang, C.S., Tzou, B.C., Liu, Y.P., Shyue, S.K., Tzeng, S.F.* 2008. Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. J Cell Biochem. 2008. Feb 15; 103(3):825-34. (IF=3.06, Ranking 125/290, 43.1% in Biochemistry & Molecular Biology category)
  14. Hsiao, H.Y., Mak, O.T., Yang, C.S., Liu, Y.P., Fang, K.M., Tzeng. S.F.* 2007. TNF-a/IFN-g-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling. Glia. 2007. Jan 15;55(2):214-23. (IF=5.07, Ranking 43/251, 17.1% in Neuroscience category)
  15. Liu, Y.P., Lin, H.I., Tzeng, S.F.* 2005. Tumor necrosis factor-a and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture. Brain Res. 2005. 1054:152-158. (IF=2.88, Ranking 126/251, 50.2% in Neuroscience category)
  16. Yeh Y.C., Hwang G.Y., Liu Y.P., Yang V.C., 2002. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Atherosclerosis. 2002. 161(1):95-103. (IF=3.71, Ranking 15/67, 22.4% in Peripheral Vascular Disease category)

研討會論文

  1. Liu Y.P. and Lu P.J.*. 2013 Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer. Abstract Number: 272466_1. Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research. Maui, Hawaii, USA
  2. Liu, Y.P., Yang C.N. and Lu, P.J.*. 2012 Cisplatin enriches drug resistance CD133 positive cells via activation of Notch Signaling in Non-small Cell Lung Cancer. International Society for Stem Cell Research. Tracking Number: 2012-P-141-ISSCR. Yokohama, Japan.
  3. Tsai, H.Y., Wu, A.T., Yang, C.J., Lim, C.H., Yang, Y.F., Liu, Y.P., Lee, C.H., Hsiao, Y.W., Jan, Y.H., Yeh, C.T., Shen, C.N., Lu, P.J., Hsiao M*. 2012 Endoplasmic reticulum ribosome binding protein1 (RRBP1) overexpression Is frequently found in lung cancer patients and alleviates intracellular stress induced apoptosis through positive regulation of GRP78 in lung cancer cells. AACR Annual Meeting, Chicago, USA, Mar. 31-Apr.
  4. Liu, Y.P. and Lu, P.J. 2011. Carboxyl-terminal modulator protein (CTMP) promotes tumorigenesis of breast cancer by enhancing Akt/PKB activation. Global Breast Cancer Conference 2011. Abst. PO03-12. (GBCC2011 Good Poster Presentation Award) Korea
  5. Liu, Y.P., Lee Y.C., Hsu, C.Y. and Lu, P.J.*. 2011 Carboxyl-terminal modulator protein is a positive regulator of Akt/PKB and plays an oncogenic role in breast cancer. International Symposium on Translational Cancer Research, Taipei, Taiwan, Nov. 20-21, 2011. Abst. 229.
  6. Tsai, H.Y., Wu, A.T., Yang, C.J., Liu, Y.P., Lee, C.H., Hsiao, Y.W., Jan, Y.H., Yeh, C.T., Shen, C.N., Huang, M.S., Lu, P.J., Hsiao, M*. 2011 RRBP1 overexpression is frequently found in lung cancer patients and alleviates intracellular stress induced apoptosis in lung cancer cell. International Symposium on Translational Cancer Research, Taipei, Taiwan, Nov. 20-21, 2011.
  7. Liu, Y.P., Lu, P.J., and Hsiao, M. 2011. Cisplatin-induced DNA damage increases the stem-like cancer cells in human non-small cell lung cancer. International Society for Stem Cell Research. Abst. #667. Canada
  8. Liu, Y.P. and Tzeng, S.F. 2007. Inhibitory regulation of glutamate aspartate transporter GLAST expression in astrocytes by cadmium-induced calcium influx. International Symposium on Cell Signaling and Gene Regulation. Abst. 29. (The best poster presentation Award) Taiwan
  9. Tzeng, S.F., Liu, Y.P. 2007. Calcium regulation of glutamate aspartate transporter GLAST in astrocytes. Brain'07 and BrainPET'07. Abst. BP48-8W. Japan
  10. Liu, Y.P., Tzou, B.C., Lin, C.C., Tzeng, S.F. 2005. Regulation of astrocytic cell viability and GLT-1 expression by cadmium. Soc. Neurosci. Abst. 30: 972.10. USA
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