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郭柏麟 教授

 Prof. Po-Lin Kuo                                                       

 KUO

連絡電話:07-312-1101 ext. 2512#33

電子信箱:kuopolin@kmu.edu.tw

                  kuopolin@seed.net.tw

辦公位置:國研大樓四樓

學歷

高雄醫學大學 天然藥物研究所

經歷

高雄醫學大學臨床醫學研究所副教授

教授課程

高級分子及細胞生物學、儀器分析及實習、專題討論

代表著作

      

1.   Hsu YL, Huang MS, Hung JY, Chang WA, Tsai YM, Pan YC, Lin YS, Tsai HP, Kuo PL*. Bone marrow derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer. Oncogene 2019 (In Press)

2.   Hsu YL, Yen MC, Chang WA, Tsai PH, Pan YC, Liao SH, Kuo PL*. CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB. Breast Cancer Research 2019 Feb 12;21(1):23

3.   Lin ES, Chang WA, Chen YY, Wu LY, Chen YJ*, Kuo PL*. Deduction of Novel Genes Potentially Involved in Keratinocytes of Type 2 Diabetes Using Next-Generation Sequencing and Bioinformatics Approaches. Journal of Clinical Medicine 2019 Jan 10;8(1). pii: 73.

4.  Chen YJ, Chang WA, Wu LY, Hsu YL, Chen CH*, Kuo PL*. Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics. Journal of Clinical Medicine 2018 Dec 10;7(12). pii: E535.

5.   Tsai MJ, Hsu YL, Kuo PL*. Circulating Extracellular Vesicles in Human Disease. New England Journal of Medicine 2018 Nov 29;379(22):2179-80.

6.   Hsu YL, Hung JY, Chang WA, Jian SF, Lin YS, Pan YC, Wu CY, Kuo PL*. Hypoxic lung cancer-derived extracellular vesicle miR-103a increases the oncogenic effects of tumor associated macrophages by targeting PTEN. Molecular Therapy 2018 Feb 7;26(2):568-81.

7.    Hsu YL, Hung JY, Chang WA, Lin YS, Pan YC, Tsai PH, Wu CY, Kuo PL*. Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1. Oncogene 2017 Aug 24;36(34):4929-42.

8.   Liu KT, Liu YH, Liu HL, Chong IW, Yen MC*, Kuo PL*. Neutrophils are Essential in Short Hairpin RNA of Indoleamine 2,3- Dioxygenase Mediated-antitumor Efficiency. Molecular Therapy-Nucleic Acids 2016 Dec 6;5(12):e397.

9.   Hsu YL, Hung JY, Chou SH, Huang MS, Tsai MJ, Lin YS, Chiang SY, Ho YW, Wu CY, Kuo PL*. Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression. Oncogene 2015 Jul 30;34(31):4056-68.

10.  Kuo PL, Huang MS, Hung JY, Chou SH, Chiang SY, Huang YF, Yang CJ, Tsai MJ, Chang WA, Hsu YL*. Synergistic effect of lung tumor-associated dendritic cell-derived HB-EGF and CXCL5 on cancer progression. International Journal of Cancer 2014 Jul 1;135(1):96-108.

11.     Hsu YL, Wu CY, Hung JY, Lin YS, Huang MS, Kuo PL*. Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin α6β4 and Notch1/Jagged2 signaling pathway. Carcinogenesis 2013 Jun;34(6):1370-81.

12. Kuo PL, Shen KH, Hung SH, Hsu YL*. CXCL1/GROα increases cell migration and invasion of prostate cancer by decreasing fibulin-1 expression through NF-κB/HDAC1 epigenetic regulation. Carcinogenesis 2012 Dec;33(12):2477-87.

13. Kuo PL*, Huang MS, Cheng DE, Hung JY, Yang CJ, Chou SH. Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. Journal of Biological Chemistry 2012 Mar 23;287(13):9753-64.

14.   Hsu YL, Huang MS, Yang CJ, Hung JY, Wu LY, Kuo PL*. Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway. Journal of Biological Chemistry 2011 Oct 28;286(43):37335-46.

15.  Hsu YL, Huang MS, Cheng DE, Hung JY, Yang CJ, Chou SH, Kuo PL*. Lung tumor-associated dendritic cell-derived amphiregulin increased cancer progression. Journal of Immunology 2011 Aug 15;187(4):1733-44.

16.  Hsu YL, Wu LY, Hou MF, Tsai EM, Lee JN, Liang HL, Jong YJ, Hung CH, Kuo PL*. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Molecular Nutrition & Food Research 2011 Feb;55(2):318-27.

17.   Kuo PL, Hung JY, Huang SK, Chou SH, Cheng DE, Jong YJ, Hung CH, Yang CJ, Tsai YM, Hsu YL*, Huang M*. Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway. Journal of Immunology 2011 Feb 1;186(3):1521-30.

18.     Hsu YL, Hung JY, Ko YC, Hung CH, Huang MS*, Kuo PL*. Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis. Carcinogenesis 2010 Apr;31(4):587-96.

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