◎學歷◎

東京女子醫科大學醫學博士
高雄醫學院醫學研究所醫學碩士
高雄醫學院醫學系醫學士

◎現職◎

高雄醫學大學 講座教授

國立陽明交通大學 合聘講座教授

高雄醫學大學附設中和紀念醫院 檢驗醫學部/小兒科部 主治醫師

台灣小兒神經醫學會 名譽理事

台灣人類遺傳學會 理事

台灣醫學會 常務理事

台灣脊髓肌肉萎縮症病友協會 常務理事

◎經歷◎

高雄醫學大學 校長(2018/8-2021/8)

國立交通大學 生物科技學院院長(2013/8-2018/8)

國立交通大學 校務發展諮詢 (2012/8-2013/7)

高雄醫學大學 副校長 (2006/7-2012/6)

高雄醫學大學 醫學院臨床醫學研究所教授 (2015/8-迄今)

高雄醫學大學 醫學院醫學研究所教授(2005/8-2015/7)

高雄醫學大學 醫學院醫學研究所所長 (2004/8-2006/7)
高雄醫學大學附設中和紀念醫院 副院長、小兒科部/臨床醫學研究部主任(2003/8-2006/7)

高雄醫學大學附設中和紀念醫院 檢驗部主任(2005/8~2006/7)
高雄市立小港醫院 院長 (2003/8-2006/7)
高雄醫學大學醫學院 醫學系實驗診斷學/小兒科學教授(2000/8-2005/7)

高雄醫學大學 研究發展處學術研究組組長/ 醫學院醫學教育發展委員會教學組組長(2001/8-2002/7)

高雄醫學大學附設中和紀念醫院 小兒神經科主任(1997/8-2000/7,

2001/8-2002/7)

高雄醫學院附設中和紀念醫院 臨床教育訓練部/教材室/教務室主任(1994/8-2000/7)

高雄醫學大學附設中和紀念醫院 臨床教育訓練部實習醫師/見習生教育訓練室主任(1993/8-2000/7)

高雄醫學院 醫學系小兒學科/檢驗學科副教授(1992/8-2000/7)

高雄醫學院 醫學系小兒學科/檢驗學科講師(1984/8-1992/7)

省立屏東醫院 小兒科(借調)主任(1991/8-1992/7)

◎榮譽與獎項◎

高雄醫學院 教育改革貢獻獎（1998）

帶領小港醫院榮獲行政院衛生署表揚防治SARS有功醫療院所（2004）

內政部兒童局及中華民國發展遲緩兒童早期療育協會合辦第三屆早期療育棕櫚獎(2005)

台灣兒科醫學會兒科醫學教育貢獻獎 (2011)

台灣兒科醫學會獎 (2013)

台灣小兒神經醫學會貢獻獎 (2020)

中華民國醫師公會全國聯合會 台灣醫療典範獎 (2021)

◎專長領域◎

小兒科學、小兒神經學、神經肌肉病學、轉譯醫學、精準醫學

◎代表性著作◎

1.      Chen TH, Chang SH, Wu YF, Yen YP, Hsu FY, Chen YC, Ming Y, Hsu HC, Su YC, Wong ST, Hung JH, Chiou SH, Jong YJ*, Chen JA*. MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice. Mol Ther Nucleic Acids 2023;32:144-60.

2.      Crawford TO*, Swoboda KJ, De Vivo DC, Bertini E, Hwu WL, Finkel RS, Kirschner J, Kuntz NL, Nazario AN, Parsons JA, Pechmann A, Ryan MM, Butterfield RJ, Topaloglu H, Ben-Omran T, Sansone VA, Jong YJ, Shu F, Zhu C, Raynaud S, Lago TR, Paradis AD, Foster R, Chin R, Berger Z; NURTURE Study Group. Continued benefit of nusinersen initiated in the presymptomatic stage of spinal muscular atrophy: 5-year update of the NURTURE study. Muscle Nerve 2023 ;68(2):157-70.

3.      Chou SH, Lin SY, Wu MH, Tien YC, Jong YJ, Liang WC, Lu YM, Shih CL, Lu CC*. Intravenous tranexamic acid reduces blood loss and transfusion volume in scoliosis surgery for spinal muscular atrophy: results of a 20-year retrospective analysis. Int J Environ Res Public Health 2021;18(19):9959.

4.      Sophelia Chan HS, Chae JH, Chien YH, Ko TS, Lee JH, Lee YJ, Nam SO, Jong YJ* Nusinersen in spinal muscular atrophy type 1 from neonates to young adult: 1-year data from three Asia-Pacific regions. J Neurol Neurosurg Psychiatry 2021;92(11):1244-6.

5.      Ou SF, Ho CS, Lee WT, Lin KL, Cynthia C Jones, Jong YJ*, SMA Study Group. Natural history in spinal muscular atrophy type I in Taiwanese population: A longitudinal study. Brain Dev 2021;43(1):127-34.

6.      Liang WC, Jong YJ*, Wang CH, Wang CH, Tian X, Chen WZ, Kan TM, Narihiro Minami, Ichizo Nishino, C Wong LJ. Clinical, pathological, imaging, and genetic characterization in a Taiwanese cohort with limb-girdle muscular dystrophy. Orphanet J Rare Dis 2020;15(1):160.

7.      Shen PC, Lu CC, Liang WC, Tien YC, Jong YJ, Lu YM, Liu ZM, Shih CL, Chou SH*. Predictors for Deformity Progression in a Spinal Muscular Atrophy Cohort After Scoliosis Correction Surgery. Clin Spine Surg. 2020;33(8):E407-14.

8.      De Vivo DC*, Bertini E, Swoboda KJ, Hwu WL, Crawford TO, Finkel RS, Kirschner J, Kuntz NL, Parsons JA, Ryan MM, Butterfield RJ, Topaloglu H, Ben-Omran T, Sansone VA, Jong YJ, Shu F, Staropoli JF, Kerr D, Sandrock AW, Stebbins C, Petrillo M, Braley G, Johnson K, Foster R, Gheuens S, Bhan I, Reyna SP, Fradette S, Farwell W, NURTURE Study Group. Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study. Neuromuscul Disord 2019;29(11):842-56.

9.      Chen TH, Liang WC, Chen IC, Liu YC, Hsu JH, Jong YJ*. Combined noninvasive ventilation and mechanical insufflator–exsufflator for acute respiratory failure in patients with neuromuscular disease: effectiveness and outcome predictors. Ther Adv Respir Dis 2019;13:1753466619875928.

10.  Wang CC, Chen CA*, Jong YJ, Kou HS. Specific gene capture combined with restriction-fragment release for directly fluorescent genotyping of single-nucleotide polymorphisms in diagnosing spinal muscular atrophy. Anal Chem 2018;90(19):11599-606.

11.  Finkel RS*, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, Chiriboga CA, Saito K, Servais L, Tizzano E, Topaloglu H, Tulinius M, Montes J, Glanzman AM, Bishop K, Zhong ZJ, Gheuens S, Bennett CF, Schneider E, Farwell W, De Vivo DC, ENDEAR Study Group. Nusinersen versus sham control in infantile-onset spinal muscular atrophy. N Engl J Med 2017;377(18):1723-32.

12.  Victor RG*, Sweeney HL, Finkel R, McDonald CM, Byrne B, Eagle M, Goemans N, Vandenborne K, Dubrovsky AL, Topaloglu H, Miceli MC, Furlong P, Landry J, Elashoff R, Cox D, Tadalafil DMD Study Group. A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy. Neurology 2017;89(17):1811-20.

13.  Chien YH, Chiang SC, Weng WC, Lee NC, Lin CJ, Hsieh WS, Lee WT, Jong YJ, Ko TM, Hwu WL*. Presymptomatic diagnosis of spinal muscular atrophy through newborn screening. J Pediatr 2017;190:124-9.

14.  Lin TL, Chen TH, Hsu YY, Cheng YH, Juang BT, Jong YJ*. Selective neuromuscular denervation in Taiwanese severe spinal muscular atrophy mouse can be reversed by morpholino antisense oligonucleotides. PLoS One 2016;11(4):e0154723.

15.  Tian X, Liang WC, Feng Y, Wang J, Zhang VW, Chou CH, Huang HD, Lam CW, Hsu YY, Lin TS, Chen WT, Wong LJ*, Jong YJ*. Expanding genotype/phenotype of neuromuscular diseases by comprehensive target capture/NGS. Neurol Genet 2015;1(2):e14.

16.  Chen TH, Hsu JH, Wu JR, Dai ZK, Chen IC, Liang WC, Yang SN, Jong YJ*. Combined noninvasive ventilation and mechanical in-exsufflator in the treatment of pediatric acute neuromuscular respiratory failure. Pediatric Pulmonol 2014;49(6):589-96.

17.  Liang WC, Hayashi YK, Ogawa M, Wang CH, Huang WT, Nishino I, Jong YJ*. Limb-girdle muscular dystrophy type 2I is not rare in Taiwan. Neuromuscu Disord 2013;23(8):675-81.

18.  Chen TH, Lai YH, Lee PL, Hsu JH, Goto K, Hayashi YK, Nishino I, Lin CW, Shih HH, Huang CC, Liang WC, Wang WF, Jong YJ*. Infantile facioscapulohumeral muscular dystrophy revisted: Expansion of clinical phenotypes in patients with a very short EcoRI fragment. Neuromuscul Disord 2013;23(4):298-305.

19.  Hsu YY, Jong YJ, Tsai HH, Tseng YT, An LM, Lo YC*. Triptolide increases SMN transcript and protein levels in human SMA fibroblasts and improves survival in SMA-like mice. Br J Pharmacol 2012;166(3):1114-26.

20.  Chen YS, Shih HH, Chen TH, Kuo CH, Jong YJ*. Prevalence and risk factors for feeding and swallowing difficulties in spinal muscular atrophy types II and III. J Pediatr 2012;160(3):447-51.

21.  Chen TH, Chang JG, Yang YH, Mai HH, Liang WC, Wu YG, Wang HY, Huang YB, Wu SM, Chen YC, Yang SN, Jong YJ*. A randomized, double-blind, placebo-controlled trial of hydroxyrea in spinal muscular atrophy. Neurology 2010;75(24):2190-7.

22.  Liang WC, Ohkuma A, Hayashi YK, López LC, Hirano M, Nonaka I, Noguchi S, Chen LH, Jong YJ*, Nishino I*. ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl CoA dehydrogenase deficiency. Neuromusc Disord 2009;19(3):212-6.

23.  Liang WC, Yuo CY, Liu CY, Lee CS, Goto K, Hayashi YK, Jong YJ*. Novel LMNA mutation in a Taiwanese family with autosomal dominant Emery-Dreifuss muscular dystrophy. J Formos Med Assoc 2007;106(2 Suppl):S27-31.

24.  Chang HC, Hung WC, Chuang YJ, Jong YJ*. Degradation of survival motor neuron (SMN) protein is mediated via the ubiquitin/proteasome pathway. Neurochem Int 2004;45(7):1107-12.

25.  Chang JG*, Hsieh-Li HM, Jong YJ, Wang NM, Tsai CH, Li H. Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci USA 2001;98(17):9808-13.

26.  Hsieh-Li HM, Chang JG, Jong YJ, Wu MH, Wang NM, Tsai CH, Li H*. A mouse model for spinal muscular atrophy. Nature Genet 2000;24(1):66-70.

27.  Jong YJ*, Chang JG, Lin SP, Yang TY, Wang JC, Chang CP, Lee CC, Li H, Hsieh-Li HM, Tsai CH. Analysis of the mRNA transcripts of the survival motor neuron (SMN) gene in the tissue of an SMA fetus and the peripheral blood mononuclear cells of normals, carriers and SMA patients. J Neurol Sci 2000;173(2):147-53.

28.  Jong YJ*, Chang JG, Wu JR. Large-scale deletions in a Chinese infant associated with a variant form of Werdnig-Hoffmann disease. Neurology 1998;51(3):878-9.

29.  Chang JG*, Jong YJ, Huang JM, Wang WS, Yang TY, Chang CP, Chen YJ, and Lin SP: Molecular basis of spinal muscular atrophy in Chinese. Am J Hum Genet 1995;57(6):1503-05.

30.  Liu GC*, Jong YJ, Chiang CH, Jaw TS. Duchenne muscular dystrophy: MR grading system with functional correlation. Radiology 1993;186(2):475-80.

31.  Liu GC*, Jong YJ, Chiang CH, Yang CW. Spinal muscular atrophy: MR evaluation. Pediatr Radiol 1992;22(8):584-6.

32.  Jong YJ*. Chuang YH, Chen SS, Chen BH, Chiang CH. Dystrophin immunostaining of muscle from Chinese patients with various neuromuscular diseases. J Formos Med Assoc 1991;90(12):1143-8.