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 S 13074437

Jeng-Hsien Yen   

        連絡電話07-312-1101 ext. 6088

        電子信箱 jehsye@kmu.edu.tw

        辦公位置國研大樓四樓

專長

免疫風濕疾病

研究領域

風濕病學、免疫遺傳學、臨床免疫學

學歷

1976/08- 1983/06 高雄醫學院醫學系學士

 1985/08- 1988/07 高雄醫學院醫學研究所碩士

 1989/08- 1996/01 高雄醫學院醫學研究所博士

工作經歷

1987- 迄今    高醫附設醫院過敏免疫風濕內科主治醫師

1997- 1998    Mayo Clinic 博士後研究員

2002         Mayo Clinic 訪問學者  

2002- 2005    高雄醫學大學醫學系 教授

2004- 2012   高雄醫學大學附設醫院臨床教育訓練部主任

歷年

1987/08迄今  高醫附設醫院過敏免疫風濕內科主治醫師

1997-1998    Mayo Clinic 博士後研究員

2002         Mayo Clinic

2002 - 2005  高雄醫學大學醫學系 教授

2003        

2004 - 2012  高雄醫學大學附設醫院臨床教育訓練部主任

2004 - 2009   高雄醫學大學附設醫院一般醫學內科主任

2004 - 2010  

2005 - 2015   高雄醫學大學醫學研究所教授

2006 - 2009   高雄醫學大學

2007 - 2009   高雄醫學大學附設醫院教師培育中心主任

2009 - 2010   高醫附設醫院內科部主任

2009 - 2015   高醫附設醫院過敏免疫風濕內科主任

2012 - 迄今高雄醫學科學雜誌編輯

2012 -    高雄醫學大學醫學院  院長

2013 - 2014   高醫附設醫院副院長

2014 - 迄今中山大學生物醫學研究所合聘教授

2015 -    高雄醫學大學臨床醫學研究所教授

2015 -    教育部醫學教育委員會委員

歷年獲得研究計畫經費補助助(近五年)

序號

計畫名稱及編號

補助單位

執行期限

計劃內
擔任之工作

 1

類風濕性關節炎病人細胞激素基因之甲基化和烴甲基化(MOST105-2314-B-037-069-MY3)

科技部

2016/08/01~

2019/07/31

主持人

 2

國家文化構面與臨床學習環境

評估及臨床教師教學表現關聯

性之探討(104-2511-S-037-

004-MY2)

科技部

2015/08/01~2017/07/31

共同主持人

 3

子計畫七、陰電性脂蛋白調控肥大細胞活化在類風溼性關節炎所扮演的病理角色(KMU-TP105D07)

頂尖計畫(高醫)

2016/11/01~

2017/10/31

主持人

 4

子計畫十三、探討陰電性低密度脂蛋白引起免疫系統老化在自體免疫疾病所扮演的角色(KMU-TP104D13)

頂尖計畫(高醫)

2015/10/01~2016/12/31

主持人

 5

探討陰電性低密度脂蛋白之溶血卵磷脂對自體免疫病人之系統性發炎反應的影響(KMU-TP103D09)

頂尖計畫(高醫)

2014/08/01~2015/12/31

主持人

 6

探討「醫學專業素養」之教育

環境認知情境個案情境學習

模式與整合評量計畫(102-

2511-S-037-004-)

科技部

2013/08/01~2014/10/31

共同主持人

 7

parvovirus B19-NS1-

VP1-VP2轉導之THP-1細胞

TNFα之表觀基因變化和

信息傳導路徑(102-2314-B-

037-051-MY3)

科技部

2013/08/01~2016/07/31

主持人

 8

探討影響痛風發生的相關基

因與表觀基因之交互作用

(101-2314-B-390-001-)

政院國家科學

委員會

2012/8/1 ~

2013/7/31

共同主持人

 9

Parvovirus B19-NS1, VP1,

VP2 基因在THP-1 cell 中對

人免疫相關基因表達的影

(99-2314-B-037-017-MY3)

政院國家科學

委員會

2010/8/1 ~

2013/7/31

主持人

期刊論文發表(近五年)

1.        Lai HMChen CJSu BYChen YCYu SFYen JHHsieh MCCheng TTChang SJ. Gout and Type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences. Rheumatology 2012; 51(4): 715-20.

2.        Wei-Chiao Chang, Peng-Yeong Woon, James Cheng-Chung Wei, Che-Mai Chang, Yu-Wen Hsu, Yuh-Cherng Guo, Daw-Yang Hwang, Yuta Kochi, Jeng-Hsien Yen*. A single nucleotide polymorphism of CCR6 (rs3093024) is associated with the susceptibility of rheumatoid arthritis but not ankylosing spondylitis in a Taiwanese population. J Rheumatol 2012; 39(8): 1765-6.

3.        Yu-Chih Lin, Jeng-HsienYen, Shun-Jen Chang, Yi-Ching Lin. The Age-Risk Relationship of Hematologic Malignancies in Female Patients with Systemic Lupus Erythematosus: A Nationwide Retrospective Cohort Study. Lupus 2012; 21: 1250-6.

4.        Ming-Ju Tsai, Chi-Tun Lien, Jong-Rung Tsai, Chen-Ching Wu, Jeng-Hsien Yen. Infective Endocarditis with Septic Shock in a Rheumatoid Arthritis Patient beingTreated with Etanercept.  Thoracic Medicine 2012; 27: 282-6.

5.        Yi-Jing Chen, Jeng-Hsien Yen*. The Roles of monocytes and SLC11a1 in the pathogenesis of Chlamydia-induced Reactive arthritis. Scand J Rheumatol 2013; 42:146-9.

6.        Hua-Chen Chan, Liang-Yin Ke, Chih-Sheng Chu, An-Sheng Lee, Ming-Yi Shen, Miguel A. Cruz, Jing-Fang Hsu, Kai-Hung Cheng, Hsiu-Chuan Bonnie Chan, Jonathan Lu, Wen-Ter Lai, Tatsuya Sawamura, Sheng-Hsiung Sheu, Jeng-Hsien Yen* and Chu-Huang Chen*.  Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood 2013; 122(22)3632-41. (* co-corresponding author)

7.        Yuan-Zhao Lin, Ruei-Nian Li, Chia-Hui Lin, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen*. Association of OSMR Gene Polymorphisms with Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients. Autoimmunity 2014 Feb; 47(1):23-6.

8.         Chen-Ching Wu, Shun-Jen Chang*, Jeng-Hsien Yen*. Gout independently contributed to occurrence of impotence in a national outpatient study. Gout and   Hyperuricemia. 2014; 1(1):16-20. (* co-corresponding author)

9.   Wan-Yu Sung, Pei-Pei Chen, Chia-Chun Tseng, Chen-Ching Wu, Tsan-Teng Ou, Wen-Chan Tsai, Jeng-Hsien Yen*. Anti-SmD and anti-Sm antibodies in the diagnosis of systemic lupus erythematosus. Fomosan J Rheumatol 2014; 28: 11-16.

10.     Yen JH, Chang CM, Hsu YW, Lee CH, Wu MS, Hwang DY, Chen BK, Liao H,  Wu M, Chang WC*. A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis. Mediaors Inflamm. 2014; 2014:834831.

10.     Liu HW, Lin HL, Yen JH, Tsai WC, Chiou SS, Chang JG, Ou TT, Wu CC, Chao NC. Demethylation within the proximal promoter region of human estrogen receptor alpha gene correlates with its enhanced expression: Implications for female bias in lupus. Mol Immunol. 2014 May 23;61(1):28-37.

11.     Chen CJ, Yen JH*, Chang SJ*. Gout patients have an increased risk of developing most cancers, especially urological cancers. Scand J Rheumatol. 2014 May 14:1-33. (* co-corresponding author)

12.    Andrew S Koenig · Karel Pavelka · Ruben Burgos-Vargas · Pedro Miranda · Renato Guzman · Jeng-Hsien Yen · Mustafa Al Izzi · Zoltan Szekanecz · Boxiong Tang · Annette Szumski. Etanercept in moderate rheumatoid arthritis: PRESERVE study results from central/eastern Europe, Latin America and Asia. Int J Clin Rheumatol 9(5):415-430, 2014.

13.     Chia-Chun Tseng, Jeng-Hsien Yen, Wen Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Ming-Chia Hsieh and Shun-Jen Chang*. Increased incidence of Sjogren’s syndrome in systemic sclerosis: A nationwide population study. Autoimmunity. 2015;48(7):438-44. Epub 2015 May 18.

14.     Tzu-Jung Fang, Chia-hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai and Jeng-Hsien Yen*. F11R mRNA expression and promoter polymorphisms in patients with rheumatoid arthritis. Int. J Rheum Dis 2015. 19(2);127-33

15.     Yu-Chin Lin, Hui-Wen Chou, Wen-Chan Tsai, Jeng-Hsien Yen, Shun-Jen Chang, Yi-Chine Lin*. The age-risk relationship of hematologic malignancies in patients with rheumatoid arthritis: a nationwide retrospective cohort study. Clin Rheumatol. 2015 Jul;34(7):1195-202. 2015 May 20.

16.     Chun-Yu Lin, Tun-Chieh Chen, Chia-Yen Dai, Ming-Lung Yu, Po-Liang Lu, Jeng-Hsien Yen, Yen-Hsu Chen*. Serological investigation to identify risk factors for post-flood infectious diseases: a longitudinal survey among people displaced by Typhoon Morakot in Taiwan. BMJ Open. 2015 May 14;5(5):e007008.

17.     Wen-Chan Tsai, Tsan-Teng Ou, Jeng-Hsien Yen, Cheng-Cing Wu, Yi-Ching  Tung*. Long-term frequent use of non-steroidal anti-inflammatory drugs might protect patients with ankylosing spondylitis from cardiovascular diseases: a nationwide case-control study.  PLoS One. 2015 May 13;10(5):e0126347.

18.    Tseng CCYen JH*, Tsai WCOu TTWu CCSung WYHsieh MCChang SJ*.  Reduced incidence of Crohn's disease in systemic sclerosis: a nationwide population study.  BMC Musculoskelet Disord. 2015 Sep 14;16:251. doi: 10.1186/s12891-015-0693-0

19.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. The association between systemic sclerosis and Behcet’s disease: a nationwide cohort study. Formosan J Rheumatol 2015; 29 (2): 1-9.

20.    Fang TJLin YZLiu CCLin CHLi RNWu CCOu TTTsai WCYen JH*Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus. Int J Rheum Dis. 2015 Oct 13. 2016 Oct;19(10):968-973. doi: 10.1111/1756-185X.12783.

21.    Tseng CCChang SJTsai WCOu TTWu CCSung WYHsieh MCYen JH*. Reduced incidence of Type 1 diabetes and Type 2 diabetes in systemic sclerosis: A nationwide cohort study. Joint Bone Spine  2016 May;83(3):307-13. doi: 10.1016/j.jbspin.2015.06.017. Epub 2015 Dec 8

22.    Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased incidence of multiple sclerosis in systemic sclerosis: A nationwide cohort study. Preventive Medicine 2016 Mar;84:6-11. doi: 10.1016/j.ypmed.2015.12.006. Epub 2015 Dec 24.

23.    Tai-Ming Ko, Chang-Youh Tsai, Shih-Yang Chen, Kuo-Shu Chen, Kuang-Hui Yu, Chih-Sheng Chu, Chung-Ming Huang, Chrong-Reen Wang, Chia-Tse Weng, Chia-Li Yu, Song-Chou Hsieh, Jer-Chia Tsai, Wen-Ter Lai, Wen-Chan Tsai, Guang-Dar Yin, Tsan-Teng Ou, Kai-Hung Cheng, Jeng-Hsien Yen, Teh-Ling Liou, Tsung-Hsien Lin, Der-Yuan Chen, Pi-Jung Hsiao, Meng-Yu Weng, Yi-Ming Chen, Chen-Hung Chen, Ming-Fei Liu, Hsueh-Wei Yen, Jia-Jung Lee, Mei-Chuan Kuo, Chen-Ching Wu, Shih-Yuan Hung, Shue-Fen Luo, Ya-Hui Yang, Hui-Ping Chuang, Yi-Chun Chou, Hung-Ting Liao, Chia-Wen Wang, Chun-Lin Huang, Chia-Shuo Chang, Ming-Ta Michael Lee, Pei Chen, Chih-Shung Wong, Chien-Hsiun Chen, Jer-Yuarn Wu, Yuan-Tsong Chen, Chen-Yang Shen For the Taiwan.  Allopurinol-SCAR Consortium. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.BMJ. 2015 Sep 23;351:h4848. doi: 10.1136/bmj.h4848.

24.     Ke LY†, Chan HC†, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced sphingomyelinase activity in apolipoprotein B100 contributes to the atherogenicity of electronegative LDL. Journal of Medicinal Chemistry 2016 Feb 11;59(3):1032-40. doi: 10.1021/acs.jmedchem.5b01534.

25.    Chia-Chun Tseng, Shun-Jen Chang, Wei-Ting Liao, Ya-Ting Chan, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Ming-Chia Hsieh, Jeng-Hsien Yen*.  Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study. Sci Rep. 2016 Jun 21;6:28175. doi: 10.1038/srep28175.

26.    Tseng CC, Chang SJ*, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased incidence of rheumatoid arthritis in multiple sclerosis: A nationwide cohort study. Medicine (Baltimore). 2016 Jun;95(26):e3999. doi: 10.1097/

27.    Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Reply to the comment of Ursini et al. "Retrospective analysis of type 2 diabetes. Prevalence in a systemic sclerosis cohort from southern Italy". Joint Bone Spine. 2016 Oct;83(5):613. doi: 10.1016/j.jbspin.2016.07.011. Epub 2016 Sep 3.

28.    Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased Incidence of Amyotrophic Lateral Sclerosis in Polymyositis: A Nationwide Cohort Study. Arthritis Care Res (Hoboken). 2017 Aug;69(8):1231-1237. doi: 10.1002/acr.23119. Epub 2017 Jul 11.

29.    Wong TH, Chen HA, Gau RJ, Yen JH, Suen JL. Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models. PLoS One. 2016 Dec 29;11(12):e0168919.

30.    Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Sex differential association of dermatomyositis with Sjögren syndrome. CMAJ. 2017 Feb 6;189(5):E187-E193. doi: 10.1503/cmaj.160783.

31.    Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Incidence réduite des diabètes de type 1 et de type 2 dans la sclérodermie systémique : étude d’une cohorte nationale. Revue du rheumatism. 2017; 83: 213-220.

32.   Chen Yi-Jing and Yen Jeng-Hsien*. Release of Tumor Necrosis Factor Alpha and Interleukin-1 Beta from THP-1 Cells Infected with Candida parapsilosis. Jundishapur journal of Microbiology. 2017 Apr ; 10(4):e39155.

33. Chung-Jen Chen, Chia-Chun Tseng, Jeng-Hsien Yen, Jan-Gowth Chang, Wen-Cheng Chou, Hou-Wei Chu, Shun-Jen Chang, Wei-Ting Liao*. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep. 2018 Feb 16;8(1):3137. doi: 10.1038/s41598-018- 21425-7.

34. Wong TH, Lee CL, Su HH, Lee CL, Wu CC, Wang CC, Sheu CC, Lai RS, Leung SY, Lin CC, Wei YF, Wang CJ, Lin YC, Chen HL, Huang MS, Yen JH, Huang SK, Suen JL. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. Sci Rep. 2018 Mar 26;8(1): 5198. doi: 10.1038/s41598-018-23542-9

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