◎聯絡方式◎

連絡電話07-312-1101 ext. 6088

電子信箱 jehsye@kmu.edu.tw

辦公位置:附設醫院啟川大樓

S 13074437

 

 

◎學歷◎

1976/08- 1983/06 高雄醫學院醫學系學士
1985/08- 1988/07 
高雄醫學院醫學研究所碩士
1989/08- 1996/01 
高雄醫學院醫學研究所博士

 

 

◎現職◎

高雄醫學大學 醫學院臨床醫學研究所 教授
高雄醫學大學附設中和紀念醫院 免疫風濕科 主任/主治醫師

 

 

◎經歷◎

1987/08迄今  高醫附設醫院過敏免疫風濕內科主治醫師

1997-1998    Mayo Clinic 博士後研究員

2002            Mayo Clinic  

2002 - 2005  高雄醫學大學醫學系 教授

2003          

2004 - 2012  高雄醫學大學附設醫院臨床教育訓練部主任

2004 - 2009   高雄醫學大學附設醫院一般醫學內科主任

2004 - 2010    

2005 - 2015   高雄醫學大學醫學研究所教授

2006 - 2009   高雄醫學大學

2007 - 2009   高雄醫學大學附設醫院教師培育中心主任

2009 - 2010   高醫附設醫院內科部主任

2009 - 2015   高醫附設醫院過敏免疫風濕內科主任

2012 - 迄今高雄醫學科學雜誌編輯

2012 - 2017高雄醫學大學醫學院  院長

2013 - 2014   高醫附設醫院副院長

2014 - 迄今中山大學生物醫學研究所合聘教授

2015 -    高雄醫學大學臨床醫學研究所教授

2015 -    教育部醫學教育委員會委員

 

◎專長領域◎

免疫風濕疾病、風濕病學、免疫遺傳學、臨床免疫學

 

◎研究發表◎

1.        Yuan-Zhao Lin, Ruei-Nian Li, Chia-Hui Lin, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen*. Association of OSMR Gene Polymorphisms with Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients. Autoimmunity 2014 Feb; 47(1): 23-6. 

2.        Chen-Ching Wu, Shun-Jen Chang*, Jeng-Hsien Yen*. Gout independently    

contributed to occurrence of impotence in a national outpatient study. Gout and Hyperuricemia. 2014; 1(1):16-20.

3.        Wan-Yu Sung, Pei-Pei Chen, Chia-Chun Tseng, Chen-Ching Wu, Tsan-Teng Ou, Wen-Chan Tsai, Jeng-Hsien Yen*Anti-SmD and anti-Sm antibodies in the diagnosis of systemic lupus erythematosus. Fomosan J Rheumatol 2014; 28: 11-16.

4.        Yen JH, Chang CM, Hsu YW, Lee CH, Wu MS, Hwang DY, Chen BK, Liao 

H, Wu M, Chang WC*. A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis. Mediaors Inflamm. 2014; 2014:834831.

5.        Liu HW, Lin HL, Yen JH, Tsai WC, Chiou SS, Chang JG, Ou TT, Wu CC, Chao NC. Demethylation within the proximal promoter region of human estrogen receptor alpha gene correlates with its enhanced expression: Implications for female bias in lupus. Mol Immunol. 2014 May 23;61(1): 28-37.

6.        Chen CJ, Yen JH*, Chang SJ*. Gout patients have an increased risk of developing most cancers, especially urological cancers. Scand J Rheumatol. 2014; 43(5): 385-90.

7.        Andrew S Koenig · Karel Pavelka · Ruben Burgos-Vargas · Pedro Miranda · Renato Guzman · Jeng-Hsien Yen · Mustafa Al Izzi · Zoltan Szekanecz · Boxiong Tang · Annette Szumski. Etanercept in moderate rheumatoid arthritis: PRESERVE study results from central/eastern Europe, Latin America and Asia. Int J Clin Rheumatol 2014; 9(5):415-30. 

8.        Chia-Chun Tseng, Jeng-Hsien Yen, Wen Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Ming-Chia Hsieh and Shun-Jen Chang*. Increased incidence of Sjogren’s syndrome in systemic sclerosis: A nationwide population study. Autoimmunity. 2015; 48(7): 438-44. 

9.        Yu-Chin Lin, Hui-Wen Chou, Wen-Chan Tsai, Jeng-Hsien Yen, Shun-Jen Chang, Yi-Chine Lin*. The age-risk relationship of hematologic malignancies in patients with rheumatoid arthritis: a nationwide retrospective cohort study. Clin Rheumatol. 2015; 34(7): 1195-202. 

10.     Chun-Yu Lin, Tun-Chieh Chen, Chia-Yen Dai, Ming-Lung Yu, Po-Liang Lu, Jeng-Hsien Yen, Yen-Hsu Chen*. Serological investigation to identify risk factors for post-flood infectious diseases: a longitudinal survey among people displaced by Typhoon Morakot in Taiwan. BMJ Open. 2015 May 14;5(5):e007008.

11.     Wen-Chan Tsai, Tsan-Teng Ou, Jeng-Hsien Yen, Cheng-Cing Wu, Yi-Ching  Tung*. Long-term frequent use of non-steroidal anti-inflammatory drugs might protect patients with ankylosing spondylitis from cardiovascular diseases: a nationwide case-control study.  PLoS One. 2015 May 13;10(5): e0126347.

12.     Tseng CCYen JH*, Tsai WCOu TTWu CCSung WYHsieh MCChang SJ*.  Reduced incidence of Crohn's disease in systemic sclerosis: a nationwide population study.  BMC Musculoskelet Disord. 2015 Sep 14; 16: 251. doi: 10.1186/s12891-015-0693-0 

13.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. The association between systemic sclerosis and Behcet’s disease: a nationwide cohort study. Formosan J Rheumatol 2015; 29 (2): 1-9.

14.     Kuo-Shu Chen, Kuang-Hui Yu, Chih-Sheng Chu, Chung-Ming Huang, Chrong-Reen Wang, Chia-Tse Weng, Chia-Li Yu, Song-Chou Hsieh, Jer-Chia Tsai, Wen-Ter Lai, Wen-Chan Tsai, Guang-Dar Yin, Tsan-Teng Ou, Kai-Hung Cheng, Jeng-Hsien Yen, Teh-Ling Liou, Tsung-Hsien Lin, Der-Yuan Chen, Pi-Jung Hsiao, Meng-Yu Weng, Yi-Ming Chen, Chen-Hung Chen, Ming-Fei Liu, Hsueh-Wei Yen, Jia-Jung Lee, Mei-Chuan Kuo, Chen-Ching Wu, Shih-Yuan Hung, Shue-Fen Luo, Ya-Hui Yang, Hui-Ping Chuang, Yi-Chun Chou, Hung-Ting Liao, Chia-Wen Wang, Chun-Lin Huang, Chia-Shuo Chang, Ming-Ta Michael Lee, Pei Chen, Chih-Shung Wong, Chien-Hsiun Chen, Jer-Yuarn Wu, Yuan-Tsong Chen, Chen-Yang Shen For the Taiwan.  Allopurinol-SCAR Consortium. Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study. BMJ. 2015 Sep 23; 351: h4848. doi: 10.1136/bmj.h4848. 

15.     Tzu-Jung Fang, Chia-hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai and Jeng-Hsien Yen*. F11R mRNA expression and promoter polymorphisms in patients with rheumatoid arthritis. Int. J Rheum Dis 2016; 19(2): 127-33.

16.     Fang TJLin YZLiu CCLin CHLi RNWu CCOu TTTsai WCYen JH*Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus. Int J Rheum Dis. 2016 Oct; 19(10): 968-9. doi: 10.1111/1756-185X.12783. 

17.     Tseng CCChang SJTsai WCOu TTWu CCSung WYHsieh MCYen JH*. Reduced incidence of Type 1 diabetes and Type 2 diabetes in systemic sclerosis: A nationwide cohort study. Joint Bone Spine  2016 May; 83(3): 307-13. doi: 10.1016/j.jbspin.2015.06.017.. 

18.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased incidence of multiple sclerosis in systemic sclerosis: A nationwide cohort study. Preventive Medicine 2016 Mar; 84: 6-11. doi: 10.1016/j.ypmed.2015.12.006.. 

19.     Tai-Ming Ko, Chang-Youh Tsai, Shih-Yang Chen, Ke LY†, Chan HC†, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein. Journal of Medicinal Chemistry 2016 Feb 11; 59(3): 1032-40. doi: 10.1021/acs.jmedchem.5b01534. 

20.     Chia-Chun Tseng, Shun-Jen Chang, Wei-Ting Liao, Ya-Ting Chan, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Ming-Chia Hsieh, Jeng-Hsien Yen*.  Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study. Sci Rep. 2016 Jun 21; 6: 28175. doi: 10.1038/srep28175. 

21.     Tseng CC, Chang SJ*, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased incidence of rheumatoid arthritis in multiple sclerosis: A nationwide cohort study. Medicine (Baltimore). 2016 Jun; 95(26): e3999. doi: 10.1097/

22.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Reply to the comment of Ursini et al. "Retrospective analysis of type 2 diabetes. Prevalence in a systemic sclerosis cohort from southern Italy". Joint Bone Spine. 2016 Oct; 83(5): 613. doi: 10.1016/j.jbspin.2016.07.011.

23.     Wong TH, Chen HA, Gau RJ, Yen JH, Suen JL. Heme xygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models. PLoS One. 2016 Dec 29; 11(12): e0168919.

24.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Increased Incidence of Amyotrophic Lateral Sclerosis in Polymyositis: A Nationwide Cohort Study. Arthritis Care Res (Hoboken). 2017 Aug; 69(8): 1231-7. doi: 10.1002/acr.23119.

25.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Sex differential association of dermatomyositis with Sjögren syndrome. CMAJ. 2017 Feb 6; 189 (5): E187-E193. doi: 10.1503/cmaj.160783.

26.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Incidence réduite des diabètes de type 1 et de type 2 dans la sclérodermie systémique : étude d’une cohorte nationale. Revue du rheumatism. 2017 May; 84(3): 213- 20. 

27.     Chen Yi-Jing and Yen Jeng-Hsien*. Release of Tumor Necrosis Factor Alpha and Interleukin-1 Beta from THP-1 Cells Infected with Candida parapsilosis. Jundishapur Journal of Microbiology. 2017 Apr ; 10(4): e39155. doi: 10.5812/jjm.39155. 

28.     Chung-Jen Chen, Chia-Chun Tseng, Jeng-Hsien Yen, Jan-Gowth Chang, Wen-Cheng Chou, Hou-Wei Chu, Shun-Jen Chang, Wei-Ting Liao*. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep. 2018 Feb 16; 8(1): 3137. doi: 10.1038/s41598-018- 21425-7. 

29.     Wong THLee CLSu HHLee CLWu CCWang CCSheu CCLai RSLeung SYLin CCWei YFWang CJLin YCChen HLHuang MSYen JHHuang SKSuen JLA prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. Sci Rep. 2018 Mar 26; 8(1): 5198. doi: 10.1038/s41598-018-23542-9 

30.     Tzu-Ching Huang, Wen-Tsan Chang, Yu-Chen Hu, Bau-Shan Hsieh, Hsiao-Ling Cheng, Jeng-Hsien Yen, Pu-Rong Chiu* and Kee-Lung Chang*. Zinc Protects Articular Chondrocytes through Changes in Nrf2-Mediated Antioxidants, Cytokines and Matrix Metalloproteinases. Nutrients 2018; 10(4): 471; doi:10.3390/nu10040471 (registering DOI)

31.     Tseng CC, Chen CJ, Yen JH, Huang HY, Chang JG, Chang SJ, Liao WT*. Next-generation sequencing profiling of mitochondrial genomes in gout. Arthritis Res Ther 2018 Jul  6; 20(1): 137.  doi: 10.1186/s13075-018-1637-5.

32.     Tseng CC, Chang SJ, Tsai WC, Ou TT, Wu CC, Sung WY, Hsieh MC, Yen JH*. Reply to “Increased Incidence of Amyotrophic Lateral Sclerosis in Polymyositis: comment on the article by Tseng et al. Arthritis Care Res (Hoboken). 2018 Jul; 70(7): 1120. doi: 10.1002/acr.23432

33.     Hung YH, Lee YH, Chen PP, Lin YZ, Lin CH, Yen JH*. Role of Salivary Immune Parameters in Patients With Primary Sjögren's Syndrome. Ann Lab Med. 2019 Jan; 39(1): 76-80. doi: 10.3343/alm.2019.39.1.76. 

34.     Tseng CC, Lin YC, Lin CH, Li RN, Tsai WC, Ou TT, Wu CC, Sung WY, Yen JH*. Genetic and Epigenetic Alteration of the Programmed Cell Death 1 (PDCD1) in Rheumatoid Arthritis. Eur J Clin Invest. 2019 Feb 27: e13094. doi: 10.1111/eci.13094.  

35.     Li RN, Lin YZ, Pan YC, Lin CH, Tseng CC, Sung WY, Wu CC, Ou TT, Tsai WC, Yen JH*GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients. J Clin Med. 2019 Jun 5;8(6). pii: E801. 

36.     Tseng CC, Wu LY, Tsai WC, Ou TT, Wu CC, Sung WY, Kuo PL, Yen JH*.

Differential Expression Profiles of the Transcriptome and miRNA Interactome in Synovial Fibroblasts of Rheumatoid Arthritis Revealed by Next Generation Sequencing. Diagnostics (Basel). 2019 Aug 18;9(3). pii: E98

37.     Tseng CC, Lin YZ, Lin CH, Li RN, Yen CY, Chan HC, Tsai WC, Ou TT, Wu CC, Sung WY, Yen JH. Next-Generation Sequencing Profiles of the

Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis. J Clin Med. 2019 Aug 22;8(9). pii: E1284. 

 

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