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中文姓名

吳明蒼

吳明蒼所長pic

英文姓名

Ming-Tsang Wu

職稱

教授

辦公室地點

濟世大樓 CS721

Office hours

Wed. 15:00~17:00

電話

(07) 3121101 ext2141-55

傳真

(07) 3221806

E-mail

960021@cc.kmuh.org.tw or

e_encourage@yahoo.com

學歷

畢業學校

主修學門系所

學位

起訖年月

美國哈佛大學

公共衛生學院

公衛博士

1993/09~1997/03

美國哈佛大學

公共衛生學院

公衛碩士

1992/09~1993/06

中山醫學院

中山醫學院

醫學士

1980/09~1987/06

經歷

服務機關

服務部門

職稱

起訖年月

小港醫院

環境職業醫療中心

主任

2010/10~2016/07

高雄醫學大學

職業安全衛生研究所

所長

2007/08~2011/07

高雄醫學大學

職業安全衛生研究所

教授

2007/02~2011/07

中國醫藥大學附設醫院

家醫科與職病科

主治醫師

2006/02~2007/01

中國醫藥大學

醫學院與公衛學院環醫所

教授

2006/02~2007/01

高雄醫學大學附設中和醫院

家庭醫學科

加聘主治醫師

2003/05~2006/01

高雄醫學大學

職業安全衛生研究所

副教授

2001/08~2004/07

高雄醫學大學附設中和醫院

職業暨環境醫學科

加聘主治醫師

2000/08~2006/01

國家衛生研究院

環境衛生與職業醫學研究組

助研究員

2000/03~2001/07

美國哈佛大學

公共衛生學院

博士後研究員

1997/04~2000/02

高雄醫學大學

家庭醫學科

醫師

1988/08~1991/07

現職

服務機關

服務部門

職稱

起訖年月

高雄醫學大學

公共衛生學系

教授兼博士班班主任

2011/08~迄今

高雄醫學大學

環境醫學研究中心

主任

2014/09~迄今

高雄醫學大學

臨床醫學研究所

所長

2014/09~迄今

高雄醫學大學附設醫院

社區醫學部

部長

2016/08~迄今

高雄醫學大學附設醫院

家醫科

主治醫師

2007/02~迄今

高雄醫學大學

環境職業醫學博士學位學程

主任

2014/09~迄今

學術專長

1.       BE分子流行病學

2.       BF公共衛生學

3.       BF 環境暨職業醫學

4.       BO社區醫學

研究興趣

1.       Clinical and Community Epidemiology

2.       Translational Medicine

任教科目

職業衛生流行病學特論、高級衛生管理實務、高級分子流行病學特論、環境職業醫學之分子流行病學特論

研究計畫

計畫名稱

補助單位

擔任工作

起訖年月

臺灣人體生物資料庫個案尿液塑化劑代謝物、三聚氰胺檢驗

中研院

主持人

2016/06~2017/05

低劑量三聚氰胺暴露與成人腎臟相關疾病之跨領域研究

科技部

主持人

2016/08~2019/07

三聚氰胺暴露與腎臟傷害之轉譯醫學研究

科技部

主持人

2015/08~2017/07

食品及飲料製造業與塑膠製品製造業及運輸工具製造修配業勞工之職業病流行病學調查

勞動部

主持人

2016/01~2016/12

金屬製品製造業與機械設備製造業及非金屬礦物製品製造業勞工之職業病流行病學調查

勞動部

主持人

2015/05~2015/11

國人尿液中三聚氰胺暴露之檢測分析

國衛院

主持人

2016/06~2016/12

三聚氰胺暴露於對成人新發生尿路鈣結石復發影響之前瞻性研究

國衛院

主持人

2013/01~2017/12

尿液中三聚氰胺濃度與成人尿路結石生成之相關性研究

科技部

主持人

2012/08~2015/07

國衛院「塑化劑等環境毒素對健康危害之防治」之全國性計畫

國衛院國家毒物研究中心

主持人

2013/01/~2014/12

期刊論文 (2012~2017)

研究著作

1

Wu IC (co-first author), Chen YK (co-first author), Wu CC, Cheng YJ, Chen WC, Ko HJ, Liu YP, Chai CY, Lin HS, Wu DC, Wu MT*: Overexpression of ATPase Na+/K+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma. Oncotarget. 2016 Dec 20;7(51):85244-85258. doi: 10.18632/oncotarget.13267..

2

Huang SH, Weng KP*, Lin CC, Wang CC, Lee Charles TC, Ger LP, Wu MT*: Maternal and umbilical cord blood levels of mercury, manganese, iron, and copper in southern Taiwan: A cross-sectional study. Journal of the Chinese Medical Association (in press)

3

Chen HM, Wu MT*: Residential exposure to chlorinated hydrocarbons from groundwater contamination and the impairment of renal function-An ecological study. Sci Reports. 2017 Jan 9;7:40283. doi: 10.1038/srep40283.

4

Tsai SY, Hsieh HM, Huang SP*, Wu MT*: Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: Multicenter case–control and case-only studies. BMC Cancer 2016 Mar 21;16(1):242.

5

Tsai WC, Haung YB, Kuo HF, Tang WH, Hsu PC, Su HM, Lin TH, Chu CS, Jhuo SJ, Lee KT, Sheu SH, Chen CY*, Wu MT*, Lai WT: Hormone replacement therapy and risk of atrial fibrillation in Taiwanese menopause women: A nationwide cohort study. Sci Reports 2016 Apr 7;6:24132.

6

Li RN, Li CY, Lee CH, Peng CY, Wu MT*: Promoter methylation status of tumor suppressor genes p16 and CDH1 in cervical intraepithelial Neoplasia. Oncol Lett (accepted).

7

Chen CC, Wang SL, Wu MT, Wang YH, Huang PC, Chen BH, Sun CW, Ho CK, Shih YC, Shiu MN, Pan WH, Chen ML, Lee CC, Hsiung CA. Exposure estimation for risk assessment of the phthalate incident in Taiwan. PLoS One. 2016 Mar 9;11(3):e0151070.

8

 Tsai YA, Lin CL, Hou JW, Huang PC, Lee MC, Chen BH, Wu MT, Chen CC, Wang SL, Lee CC, Hsiung CA, Chen ML; RAPIT Group. Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population. Environ Res. 2016 May 19;149:197-205.

9

 Tai SY, Huang SP, Bao BY, Wu MT*: Urinary melatonin-sulfate / cortisol ratio and the presence of prostate cancer: A case-control study. Sci Reports 2016 Jul 8;6:29606. doi: 10.1038/srep29606.

10

Chen YK, Tung CW, Lee JY, Hung YC, Lee CH, Chou SH, Lin HS, Wu MT, Wu IC*: Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma. Sci Reports 2016 Jul 20;6:30057. doi: 10.1038/srep30057.

11

Tai SY, Lin FC, Lee CY, Chang CJ, Wu MT, Chien CY*: Statin use after intracerebral hemorrhage: a 10-year nationwide cohort study. Brain Behav. 2016 May 13:e00487.

12

 Tsai HJ, Wu CF, Tsai YC, Huang PC, Chen ML, Wang SL, Chen BH, Chen CC, Wu WC, Hsu PS, Hsiung C*, Wu MT*: Intake of phthalate-tainted foods and serum thyroid hormones in Taiwanese children and adolescents. Sci Reports 2016 Jul 29;6:30589. doi: 10.1038/srep30589 .

13

 Chang K, Chen CD, Shih CM, Lee TC, Wu MT, Wu DC, Chen YH, Hung CH, Wu MC, Huang CC, Lee CH*, Ho CK*. Time-lagging interplay effect and excess risk of meteorological/mosquito parameters and petrochemical gas explosion on dengue incidence. Sci Reports. 2016 Oct 13;6:35028. doi: 10.1038/srep35028 (Impact Factor: 5.228, Rank: 7/62)

14

Wu IC (co-first author), Chen YK (co-first author), Wu CC, Cheng YJ, Chen WC, Ko HJ, Liu YP, Chai CY, Lin HS, Wu DC, Wu MT*: Overexpression of ATPase Na+/K+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma. Oncotarget (in press).

15

Huang SH, Weng KP*, Lin CC, Wang CC, Lee Charles TC, Ger LP, Wu MT*: Maternal and umbilical cord blood levels of mercury, manganese, iron, and copper in southern Taiwan: A cross-sectional study. Journal of the Chinese Medical Association (in press)

16

Chen HM, Wu MT*: Residential exposure to chlorinated hydrocarbons from groundwater contamination and the impairment of renal function-An ecological study. Sci Reports. 2017 Jan 9;7:40283. doi: 10.1038/srep40283.

17

Lin MY, Chiu YW, Chang JS, Lin HL, Lee TC, Chiu GF, Kuo MC, Wu MT, Chen HC, Hwang SJ:  Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease. Kidney Int 88(6):1365-1373, 2015.

18

Wu MT*, Wu CF, Chen BH: Behavioral intervention decreases daily melamine exposure from melamine tableware. Environ Sci Technol. 2015 Aug 18;49(16):9964-70. (Impact factor: 5.330; Ranking: 10/221 = 0.045; subject categories ENVIRONMENTAL SCIENCES)

19

Hou JW, Lin CL, Tsai YA, Chang CH, Liao KW, Yu CJ, Yang W, Lee MJ, Huang PC, Sun CW, Wang YH, Lin FR, Wu WC, Lee MC, Pan WH, Chen BH, Wu MT, Chen CC, Wang SL, Lee CC, Hsiung CA, Chen ML. The effects of phthalate and nonylphenol exposure on body size and secondary sexual characteristics during puberty. Int J Hyg Environ Health. 2015 Oct;218(7):603-15

20

Liu CC, Hsieh HM, Wu CF, Hsieh TJ, Huang SP, Chou YH, Huang CN, Wu WJ, Wu MT*: Long-term prescription of α-blockers decrease the risk of recurrent urolithiasis needed for surgical intervention-a nationwide population-based study. PLoS One  2015 Apr 13;10(4):e0122494

21

Kuo FC, Su SW, Wu CF, Huang MC, Shiea J, Chen BH, Chen YL, Wu MT*: Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns - A prospective birth cohort in Taiwan. PLoS One Jun 4;10(6):e0123884, 2015.

22

Chien CY, Tai SY, Wang LF, Hsi E, Chang NC, Wu MT, Ho KY. Metabolic syndrome increases the risk of sudden sensorineural hearing loss in Taiwan: A case-control study. Otolaryngol Head Neck Surg. 2015 Jul;153(1):105-11.

23

Wu IC, Hsieh HM, Wu MT*. A short-term risk-benefit analysis of occasional and regular use of low-dose aspirin in primary prevention of vascular diseases: A nationwide population-based study. BMJ Open 2015;5(1):e006694.

24

Wu WC, Lin PC, Hung CC, Lin HH, Cheng CM, Lee CY, Chiu KF, Lin WY, Huang CT, Wu MT*. Clinical risk factors of pre-diabetes in Taiwanese women without substance uses (tobacco, alcohol, or areca nut). J Formos Med Assoc 2015 Dec;114(12):1233-9.

25

Wu CF, Peng CY, Liu CC, Lin WY, Pan CH, Cheng CM, Hsieh HM, Hsieh TJ, Chen BH, Wu MT*. Ambient melamine exposure and urinary biomarkers of early renal injury. J Am Soc Nephrol 2015 Nov;26(11):2821-9.  (Impact factor: 9.343; Renal & Urology: 3/76)

26

Lee CH, Peng CY, Li RN, Chen YC, Tsia HT, Hung YH, Chan TF, Huang HL, Lai TC, Wu MT*: Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes. Int J Cancer 136(2):340-9, 2015.

27

Lin FC, Tsai CP, Lee KW, Wu MT, Lee TC. Angiotensin-converting enzyme inhibitors and amyotrophic lateral sclerosis risk: A total population-based case-control study. JAMA Neurol. 2014 Nov 10.

28

Wu IC, Hsieh HM, Wu MT*. A short-term risk-benefit analysis of occasional and regular use of low-dose aspirin in primary prevention of vascular diseases: A nationwide population-based study. BMJ Open 2015;5(1):e006694.

29

Wu WC, Lin PC, Hung CC, Lin HH, Cheng CM, Lee CY, Chiu KF, Lin WY, Huang CT, Wu MT*. Clinical risk factors of pre-diabetes in Taiwanese women without substance uses (tobacco, alcohol, or areca nut). J Formos Med Assoc (in press).

30

Kuo FC, Wu CY, Kuo CH, Wu CF, Lu CY, Chen YH, Chen CY, Lo YC, Wu MT, Hu HM: The utilization of a new immunochromatographic test in detection of Helicobacter pylori antibody from maternal and umbilical cord serum. Biomed Res Int. 2014;2014:568410

31

Lin PC, Chen CH, Pan SM, Chen YM, Pan CH, Hung HC,* Wu MT*: The association between rotation shift work and increased occupational stress in nurses. J Occup Health (in press)

32

Pan CH, Chen CJ, Wu MT, Lin WY: C-reactive protein evaluation for polycyclic aromatic hydrocarbons exposed workers. J Occup Safety Health 22:102-111, 2014. (潘致弘、陳秋蓉、吳明蒼、林文一:多環芳香族碳氫化合物暴露對勞工C反應蛋白影響評估研究。勞工安全衛生季刊22:102-111, 2014. )

33

Wu IC, MD, Lin MY, Yu FJ, Hsieh HM, Chiu KF, Wu MT*: A short-term effect of low-dose aspirin on major hemorrhagic risks in primary prevention: A case-crossover design. PLoS One 9(5):e98326, 2014.

34

Kuo CY, Wang HC, Kung PH, Lu CY, Liao CY, Wu MT, Wu CC. Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets. Thromb Haemost. 111: 892–901, 2014.

35

Tai SY, Lin PC, Chen YM, Hung HC, Pan CH, Pan SM, Lee CY, Huang CT, Wu MT*: Effects of marital status and shift work on family function among registered nurses. Ind Health 52(4):296-303, 2014.

36

Wu CF, Chang-Chien GP, Su SW, Chen BH, Wu MT*: Findings of 2,731 suspected phthalate-tainted foodstuffs during the 2011 phthalate incident in Taiwan. J Formos Med Assoc 113: 600-605, 2014.

37

 Li RN, Yu FJ, Wu CC, Chen YK, Yu CC, Chou SH, Lee JY, Cheng YJ, Wu MT, Wu IC: Methylation status of retinoic acid receptor beta2 promoter and global DNA in esophageal squamous cell carcinoma. Journal of Surgical Oncology 2014 Feb 10.

38

 Wu CF, Liu CC, Chou YH, Shiea J, Shen JT, Wang HS, Wu MT*: Increased detection rate of melamine-containing calcium urolithiasis by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry technique in clinical practice. Clin Chim Acta 2014 Apr 20;431:294-8.

39

Lee HH, Lee JF, Lin SY, Lin YY, Wu CF, Wu MT, Chen BH: Simultaneous quantification of urine flunitrazepam, nimetazepam and nitrazepam by using liquid chromatography tandem mass spectrometry. Clin Chim Acta 420: 134-9, 2013.

40

Tsai WC, Lee KT, Wu MT, Chu CS, Lin TH, Hsu PC, Su HM, Voon WC, Lai WT, Sheu SH. Significant correlation of P-wave parameters with left atrial volume index and left ventricular diastolic function. Am J Med Sci. 346(1):45-51, 2013.

41

 Lin MY, Chiu YW, Lee CH, Yu HY, Chen HC, Wu MT, Hwang SJ. Factors Associated with CKD in the Elderly and Nonelderly Population. Clin J Am Soc Nephrol. 2013 Jan;8(1):33-40.

42

Wu MT*, Wu CF, Chen BH, Chen EK, Chen YL, Shiea J, Lee WT, Chao MC, Wu JR*: Intake of Phthalate-tainted Foods Alters Thyroid Functions in Taiwanese Children. PLoS One 2013;8(1):e55212. (NSC 100-3114-Y-043-005, KMUH100-0R55, and KMUH101-1I04)

43

Wu IC, Wu CC, Lu CY, Hsu WH, Wu MC, Lee JY, Chou SH, Lee JM, Chou YP, Wu DC, Wu MT*. Substance use (alcohol, areca nut and cigarette) is associated with poor prognosis of esophageal squamous cell carcinoma. PLoS One. 2013;8(2):e55834.

44

Tsai JH, Yang P, Lin HH, Cheng KH, Yang YH, Wu MT, Chen CC. Association between GABA(A) Receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese. Sleep. 2013 Feb 1;36(2):197-202.

45

Tsai EM, Wang YS, Lin CS, Lin WY, Hsi E, Wu MT, Juo SH. A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women. J Hum Genet. 58(4):202-9, 2013.

46

Tsai WC, Chen CY, Kuo HF, Wu MT, Tang WH, Chu CS, Lin TH, Su HM, Hsu PC, Jhuo SJ, Lin MY, Lee KT, Sheu SH, Lai WT: Areca nut chewing and risk of atrial fibrillation in Taiwanese men: A nationwide ecological study. Int J Med Sci. 10: 804-11, 2013.

47

Kuo FC, Tseng YT, Wu SR, Wu MT, Lo YC. Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. Toxicol In Vitro. 2013 Apr 30;27(6):1603-1611.

48

Ou CH, Kuo FC, Hsu WH, Lu CY, Yu FJ, Kuo CH, Wang JY, Wu MT, Shiea J, Wu DC, Hu HM. Comparison of the performance of guaiac-based and two immunochemical fecal occult blood tests for identifying advanced colorectal neoplasia in Taiwan. J Dig Dis. 14(9):474-83, 2013.

49

 Lin CH, Wu CY, Kou HS, Chen CY, Huang MC, Hu HM, Wu MC, Lu CY, Wu DC, Wu MT, Kuo FC: Effect of Di(2-ethylhexyl)phthalate on Helicobacter pylori-induced Apoptosis in AGS cells. Gastroenterology Research and Practice (accepted)

50

 Wu CF, Chen BH, Shiea J, Chen EK, Liu CK, Chao MC, Ho CK, Wu JR, Wu MT*: Temporal changes of urinary oxidative metabolites of di(2-ethylhexyl)phthalate  after the 2011 phthalate incident in Taiwanese children-Findings of a 6-month follow-up. Environ Sci Technol. 47(23):13754-62, 2013.

51

Tung CW, Wu MT, Chen YK, Wu CC, Chen WC, Li HP, Chou SH, Wu DC, Wu IC: Identification of biomarkers for esophageal squamous cell carcinoma using feature selection and decision tree methods. The Scientific World Journal 2013 Dec 12;2013:782031..

52

 Lin CH, Wu CY, Kou HS, Chen CY, Huang MC, Hu HM, Wu MC, Lu CY, Wu DC, Wu MT, Kuo FC: Effect of di(2-ethylhexyl)phthalate on helicobacter pylori-induced apoptosis in AGS cells. Gastroenterology Research and Practice, Article ID 924769, 8 pages, 2013.

53

Huang SH, Wu IC, Wu DC, Wu CC, Yang JF, Chen YK, Chai CY, Chiu YW, Huang CT, Wu MT*: Occupational risks of esophageal cancer in Taiwanese men. Kaohsiung J Med Sci 2012 Dec;28(12):654-9.

54

Liu CC* (equal contribution), Wu CF* (equal contribution), Shiea J, Cho YT, Hsieh TJ, Chou YH, Chen BH, Huang SP, Wu WJ, Shen JT, Chang MY, Huang CH, Chang AW, Wu MT*: Detection of Melamine in a Human Renal Uric Acid Stone by Matrix-Assisted Laser Desorption / Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS). Clin Chim Acta 413(19-20): 1689-1695, 2012. (correspondent).

55

Hsieh TJ, Hsieh PC, Tsai YH, Wu CF, Liu CC, Lin MY, Wu MT*: Melamine induces human renal proximal tubular cell injury via transforming growth factor-beta and oxidative stress. Toxicol Sci 2012 Nov;130(1):17-32. (correspondent).

56

Wu CF, Hsieh TJ, Chen BH, Liu CC, Wu MT*: A crossover study of noodle soup consumption in melamine bowls and total melamine excretion in urine. Arch Int Med 2013 Feb 25;173(4):317-9. (correspondent).

57

Lin YT (equal contribution), Tsai MT (equal contribution), Chen YL, Cheng CM, Huang CC, Wu CF, Liu CC, Hsieh TJ, Shiea J, Chen BH, Wu MT*: Can melamine levels in one-spot overnight urine specimen predict the total previous 24-hours melamine excretion in school children?  Clin Chim Acta 420: 128–133, 2013. (correspondent).

58

Chien CY, Chang NC, Tai SY, Wang LF, Wu MT, Ho KY. Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. Audiol Neurootol. 17(6):381-5, 2012.

59

Huang SP, Bao BY, Wu MT, Choueiri TK, Goggins WB, Liu CC, Huang CY, Pu YS, Yu CC, Wu TT, Huang CN, Huang CH, Wu WJ. Significant associations of prostate-specific antigen nadir and time to prostate-specific antigen nadir with survival in prostate cancer patients treated with androgen-deprivation therapy. Aging Male 2012 Mar;15(1):34-41.

60

Lin PC, Chen CH, Pan SM, Pan CH, Chen CJ, Chen YM, Hung HC*, Wu MT*: Atypical work schedules are associated with poor sleep quality and mental health in Taiwan female nurses. Int Arch Occup Environ Health 2012 Nov;85(8):877-84.

61

Liu CC, Wu CF, Wu MT*: Reappraisal of melamine exposure and adult calcium urolithiasis. Kidney Int [Letter] 82(3):361-2, 2012.

62

Wu MT*, Wu CF, Wu JR, Chen BH, Chen EK, Chao MC, Liu CK, Ho CK*: The public health threat of phthalate-tainted foodstuffs in Taiwan: the policies the government implemented and the lessons we learned. Environ Int 44: 75-79, 2012.

63

Tsai WC, Wu MT, Wang GJ, Lee KT, Lee CH, Lu YH, Yen HW, Chu CS, Chen YT, Lin TH, Su HM, Hsu PC, Cheng KH, Duh TH, Ko YC, Sheu SH, Lai WT: Chewing areca nut increases the risk of coronary artery disease in Taiwanese men: A case-control study. BMC Public Health 2012;12(1):162.

 

                 

 

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